This project will work towards the adoption of a nationwide approach to identify gaps in detection and control strategies of the CCHF (a dangerous agent on the U.S. Select Agent List that has a nearly 50 percent case fatality rate) in four Afghanistan provinces with active terrorist groups. The work will focus on efforts initiated during a pilot phase targeting six provinces to help mitigate biological threats in the most critical regions of Afghanistan where endemic CCHF and terrorist groups coexist, namely Herat, Nangarhar, Balk, and Kandahar, and which are also home to active regional laboratories. Specific activities will include work to identify vectors collected from the field, map high-risk locations for presence of the virus, provide diagnostic and testing capacities at the Central Veterinary Diagnostic Research Laboratory (CVDRL) for CCHF with education and vector identification at the Regional Laboratories, and statistically correlate the variables that increase the threat burden from CCHF in a geographical area. Enhanced early detection of CCHF allows for rapid and targeted interventions to halt the spread of the virus and minimize the reservoir of weaponizable pathogens that could be exploited by terrorists or other nefarious actors for use in a bioterrorism attack.